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Variation of intracellular Ca2+ following Ca2+ current in heart. A theoretical study of ionic diffusion inside a cylindrical cell.

机译:心脏中的钙离子流后细胞内钙离子的变化。圆柱状电池内部离子扩散的理论研究。

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摘要

The variation in the concentration of a diffusing substance inside a cylindrical cell submitted to a time-dependent flux at the sarcolemmal membrane was studied theoretically. An application was derived to estimate the local modifications of intracellular free Ca2+ concentration ([CA2+]i) induced by the slow inward Ca2+ current (ICa) in frog heart. During a O mV voltage clamp depolarization, [Ca2+]i at the inner side of the membrane rises earlier and faster than [Ca2+]i at the center of the cell. The binding of intracellular Ca2+ to specific sites enhances the deviation between the two concentrations and may generate an accumulation-depletion process of Ca2+ near the membrane. However, it also decreases the overall [Ca2+]i. The relatively slow diffusion of sarcoplasmic Ca2+ does not significantly affect the kinetics of ICa through a modification in the Ca2+ gradient across the membrane.
机译:从理论上研究了圆柱形细胞内部扩散物质的浓度随时间变化在肌膜上的变化。推导了一个应用,以评估青蛙心脏中缓慢的内向Ca2 +电流(ICa)诱导的细胞内游离Ca2 +浓度([CA2 +] i)的局部修饰。在O mV电压钳去极化过程中,膜内侧的[Ca2 +] i比细胞中心的[Ca2 +] i上升得更快。细胞内Ca2 +与特定位点的结合会增加两个浓度之间的偏差,并可能在膜附近产生Ca2 +的积累-耗尽过程。但是,它也降低了整体[Ca2 +] i。肌浆Ca2 +的相对较慢的扩散不会通过跨膜的Ca2 +梯度的改变而显着影响ICa的动力学。

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